Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

After an acute ischemic stroke (AIS), inflammatory processes are able to concomitantly
induce both beneficial and detrimental effects. In this narrative review, we updated evidence …

Background and Purpose—Although experimental data suggest that statin therapy may
improve neurological outcome after acute cerebral ischemia, the results from clinical studies …

Nucleotides and cysteinyl‐leukotrienes (CysLTs) are unrelated signaling molecules
inducing multiple effects through separate G‐protein‐coupled receptors: the P2Y and the …

Clinical trials report that the class of drugs known as statins may be neuroprotective in
Alzheimer's and Parkinson's disease, and further trials are currently underway to test …

Nitric oxide (NO) generated by endothelial NO synthase (eNOS) plays a crucial role in
vascular function and homeostasis. NO possesses vasodilatory, anti-inflammatory …

Admission hyperglycemia complicates approximately one-third of acute ischemic strokes
and is associated with a worse clinical outcome. Both human and animal studies have …

The past decade has witnessed unprecedented medical progress, which has translated into
cardiac surgery being increasingly common and safe. However, complications such as …