Rationale Autism spectrum disorder (ASD) is a complex heterogeneous
neurodevelopmental disorder with onset during early childhood and typically a life-long …

Assembling peptides identified from tandem mass spectra into a list of proteins, referred to
as protein inference, is a critical step in proteomics research. Due to the existence of …

Under resting conditions, Pink1 knockout cells and cells derived from patients with PINK1
mutations display a loss of mitochondrial complex I reductive activity, causing a decrease in …

Mitochondria import a large number of nuclear-encoded proteins via membrane-bound
transport machineries; however, little is known about regulation of the preprotein …

The initiation of cytotoxic immune responses by dendritic cells (DCs) requires the
presentation of antigenic peptides derived from phagocytosed microbes and infected or …

Background: The function and physiological substrates of BACE1 remain largely unknown.
Results: Novel substrates for BACE1 were identified using large scale proteome analysis; L1 …

Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global
scale has remained obscure. Using genome-wide CRISPR knockout screens in human …

Motivation: Tandem mass spectrometry provides the means to match mass spectrometry
signal observations with the chemical entities that generated them. The technology …

Clathrin-mediated endocytosis (CME) is a highly conserved and essential cellular process in
eukaryotic cells, but its dynamic and vital nature makes it challenging to study using …

Abstract Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics,
yet mechanistic links have remained elusive. T1D results from autoimmune destruction of …