Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more
than four decades, transcription enhances mutation and recombination frequencies. More …

PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …

Transcription-replication collisions (TRCs) are crucial determinants of genome instability. R-
loops were linked to head-on TRCs and proposed to obstruct replication fork progression …

Prolonged pausing of the transcription machinery may lead to the formation of three-
stranded nucleic acid structures, called R-loops, typically resulting from the annealing of the …

Nuclear pore complexes (NPCs) have increasingly recognized interactions with the
genome, as exemplified in yeast, where they bind transcribed or damaged chromatin. By …

Uncoordinated clashes between replication forks and transcription cause replication stress
and genome instability, which are hallmarks of cancer and neurodegeneration. Here, we …

Replication forks stalled at co-transcriptional R-loops can be restarted by a mechanism
involving fork cleavage-religation cycles mediated by MUS81 endonuclease and DNA …

Transcription stress has been linked to DNA damage-driven aging, yet the underlying
mechanism remains unclear. Here, we demonstrate that Tcea1−/− cells, which harbor a …

DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is
crucial for cell viability and genome integrity. The readout of DSB repair may depend on …