Insights into the effects of mesenchymal stem cell-derived secretome in Parkinson's disease

M d'Angelo, A Cimini, V Castelli - International Journal of Molecular …, 2020 - mdpi.com
Mesenchymal stem cell (MSC)-derived secretome demonstrated therapeutic effects like
those reported after MSCs transplantation. MSC-derived secretome may avoid various side …

Adipose-derived stem cell-conditioned medium protects fibroblasts at different senescent degrees from UVB irradiation damages

S Guo, T Wang, S Zhang, P Chen, Z Cao… - Molecular and Cellular …, 2020 - Springer
Adipose-derived stem cells (ADSCs) and their derivatives have aroused intense interest in
fields of dermatological and aesthetic medicine. As a major component detected in ADSCs …

Pentraxin 3 secreted by human adipose‐derived stem cells promotes dopaminergic neuron repair in Parkinson's disease via the inhibition of apoptosis

C Lian, Q Huang, X Zhong, Z He, B Liu… - The FASEB …, 2021 - Wiley Online Library
Although adipose‐derived human mesenchymal stem cell (hADSC) transplantation has
recently emerged as a promising therapeutic modality for Parkinson's disease (PD), its …

Comparative study between bone marrow mesenchymal stem cell and their conditioned medium in the treatment of rat model of Parkinsonism

S Abdelwahab, SAG Elsebay… - Journal of Cellular …, 2021 - Wiley Online Library
Parkinsonism is one of the most common aging neurodegenerative disorders. This study
aims to compare the therapeutic effect of stem cell versus its conditioned medium in the …

Cerebral and cerebellar histological changes in the rat animal model of rotenone induced parkinsonism can be ameliorated by bone marrow derived stem cell …

SA Abdelwahab, SAG Elsebay, MFG Ibrahim… - Journal of Chemical …, 2021 - Elsevier
Parkinson disease is the second most common neurodegenerative disease affecting elderly
patients. It occurs due to the progressive degeneration of dopaminergic neurons in the …

Conditioned medium from Endothelial Progenitor Cells promotes number of dopaminergic neurons and exerts neuroprotection in cultured ventral mesencephalic …

S Di Santo, S Seiler, AD Ducray, HR Widmer - Brain research, 2019 - Elsevier
Transplantation of stem and progenitor cells offers a promising tool for brain repair in the
context of neuropathological disorders including Parkinson's disease. There is growing …

Stem cell conditioned medium as a novel treatment for neuroinflamation diseases

S Mehrabadi, SS Sadr, M Hoseini - International journal of medical …, 2019 - intjmi.com
Inflammation is a most important factor that mentioned as causes of many
neurodegeneration disease like Parkinson, Alzheimer and ALS. Neuroinflammation is …

[HTML][HTML] Expression of Neurotrophins in Adipose-derived Stem Cells during in vitro Culture and Posttransplantation in Parkinsonian Rat Model

A Kousha, M Haji Ghasem Kashani… - Iranian South Medical …, 2022 - ismj.bpums.ac.ir
Background: Adipose tissue stem cells (ASCs) cause faster repair of damaged tissue
posttransplantation by releasing growth factors in neurodegenerative diseases. ASCs …

[HTML][HTML] Mesenchymal Stem Cell-Derived Exosomes as a New Possible Therapeutic Strategy for Parkinson's Disease

Z Zhang, J Kong, S An - 2023 - intechopen.com
Mesenchymal stem cell-derived exosomes (MSC-Exos) are nano-sized extracellular
vesicles that have low immunogenicity and the ability to transfer the effective substances …

Protective effect of conditioned medium from brain pericytes overexpressing telomerase reverse transcriptase on hypoxic-ischemic neurons

S Liu, L Huang, Z Zheng, M Zhang, H Li, F Zhao… - 2023 - researchsquare.com
Aims: Cerebral microvascular pericytes can secrete both neurotrophic factors and neurotoxic
molecules, which together construct the microenvironment for nerve growth and repair. The …