The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

Mitophagy is an evolutionarily conserved cellular process to remove dysfunctional or
superfluous mitochondria, thus fine-tuning mitochondrial number and preserving energy …

Aging is a general degenerative process related to deterioration of cell functions in the entire
organism. Mitochondria, which play a key role in energy homeostasis and metabolism of …

Multiple cancers regulate oxidative stress by activating the transcription factor NRF2 through
mutation of its negative regulator, KEAP1. NRF2 has been studied extensively in KEAP1 …

Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling
molecules that control various cellular functions. Nrf2 governs the gene expression of …

Mitochondria are organelles with a highly dynamic ultrastructure maintained by a delicate
equilibrium between its fission and fusion rates. Understanding the factors influencing this …

Ferroptosis is a newly described form of regulated cell death, distinct from apoptosis,
necroptosis and other forms of cell death. Ferroptosis is induced by disruption of glutathione …

Elevated concentration of homocysteine (Hcy) in the blood plasma, hyperhomocysteinemia
(HHcy), has been implicated in various disorders, including cardiovascular and …

Mitochondria in aerobic eukaryotic cells are both the site of energy production and the
formation of harmful species, such as radicals and other reactive oxygen species, known as …

Nrf2 is a basic region leucine-zipper transcription factor that plays a pivotal role in the
coordinated gene expression of antioxidant and detoxifying enzymes, promoting cell …