Vimentin is a structural protein that is required for mesenchymal cell migration and directly
interacts with actin, β1 integrin and paxillin. We examined how these interactions enable …

Following myocardial infarction (MI), cardiac myofibroblasts remodel the extracellular matrix
(ECM), preventing mechanical complications. However, prolonged myofibroblast activity …

Collagen cross-linking is an important step in optimal scar formation. Myocardial infarction
(MI) results in loss of cardiomyocytes that are replaced with a scar (infarct) tissue. Disintegrin …

Focal adhesion kinase (FAK) is critical for collagen expression but its regulation of collagen
remodeling is not defined. We examined the role of FAK in the degradation and …

The generation of cell extensions is critical for matrix remodeling in tissue invasion by
cancer cells, but current methods for identifying molecules that regulate cell extension …

PAK kinases belong belong to the family of STE kinases, named after the yeast STE7,
STE11 and STE20 genes, which form the MAPK cascade, transducing signals from the …

Vimentin is a structural protein that is required for mesenchymal cell migration and directly
interacts with actin, β1 integrin and paxillin. We examined how these interactions enable …

Encore en 2015, un grand nombre d'individus décèdent de pathologies du rythme
cardiaque non contrôlées ou d'un manque de disponibilité de donneurs d'organes …

Le remodelage du ventricule gauche cardiaque post-infarctus est multifactoriel et bien
connu. Il est caractérisé par un changement électrophysiologique, une fibrose et une mort …