Reducing the burden of infectious diseases that affect people in the developing world
requires sustained collaborative drug discovery efforts. The quality of the chemical starting …

The WHO recognizes human African trypanosomiasis, Chagas disease and the
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …

Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

Highlights•Leishmaniasis remains a neglected tropical disease, with a high unmet medical
need.•Therapeutic efficacy varies depending on the species of Leishmania parasite.•Leads …

Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS)
diversity set of 1.8 million compounds was screened against the three kinetoplastids most …

Visceral leishmaniasis (VL), caused by the protozoan parasites Leishmania donovani and
Leishmania infantum, is one of the major parasitic diseases worldwide. There is an urgent …

Background: Neglected tropical diseases (NTDs) are closely related to poverty and affect
over a billion people in developing countries. The unmet treatment needs cause high …

Visceral leishmaniasis causes considerable mortality and morbidity in many parts of the
world. There is an urgent need for the development of new, effective treatments for this …

Leishmaniasis is a vector-borne parasitic disease caused by Leishmania species. The
disease affects humans and animals, particularly dogs, provoking cutaneous …

Tritryps diseases are devastating parasitic neglected infections caused by Leishmania spp.,
Trypanosoma cruzi and Trypanosoma brucei subspecies. Together, these parasites affect …