When compared to other organisms, plants are atypical with respect to isoprenoid
biosynthesis: they utilize two distinct and separately compartmentalized pathways to build …

Identification of regulatory enzymes is fundamental for engineering metabolic pathways
such as the isoprenoid one. All too often, investigation of gene expression remains the major …

Isoprenoids comprise a large class of chemicals of significant interest due to their diverse
properties. Biological production of isoprenoids is considered to be the most efficient way for …

In plants, two pathways are utilized for the synthesis of isopentenyl diphosphate, the
universal precursor for isoprenoid biosynthesis. The key enzyme of the cytoplasmic …

Plants produce a large variety of lipids that lack fatty acid moieties and are often called
nonacyl lipids. The largest single category of nonacyl lipids in higher plants is undoubtedly …

Engineering microbes for the production of valuable natural products is often hindered by
the regulation of native competing metabolic networks in host. This is particularly evident in …

A genomic fragment encoding one (HMGR1) of the three 3-hydroxy-3-methylglutaryl
coenzyme A reductases (HMGRs) from Hevea brasiliensis (HBK) Mull. Arg.(M.-L. Chye, C.-T …

Expression of foreign pathways often results in suboptimal performance due to unintended
factors such as introduction of toxic metabolites, cofactor imbalances or poor expression of …

The enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR; EC 1.1. 1.34) catalyzes the
first rate-limiting step in plant isoprenoid biosynthesis. Arabidopsis thaliana contains two …

Certain Taraxacum species, such as Taraxacum koksaghyz and Taraxacum
brevicorniculatum, produce large amounts of high-quality natural rubber in their latex, the …