Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …

Dextromethorphan (DM) has been used for more than 50 years as an over-the-counter
antitussive. Studies have revealed a complex pharmacology of DM with mechanisms …

Sepsis is an often deadly complication of infection in which systemic inflammation damages
the vasculature, leading to tissue hypoperfusion and multiple organ failure. Currently, the …

The past decade has seen the emergence of endoplasmic reticulum (ER) chaperones as
key determinants of contact formation between mitochondria and the ER on the …

This review compares the biological and physiological function of Sigma receptors [σRs] and
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …

The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …

Sigma receptors (sigma-1 and sigma-2) represent two independent classes of proteins.
Their endogenous ligands may include the hallucinogen N, N-dimethyltryptamine (DMT) …

Depression and cognitive disorders are diseases with complex and not-fully understood
etiology. Unfortunately, the COVID-19 pandemic dramatically increased the prevalence of …

The tri-nucleotide repeat expansion underlying Huntington disease (HD) results in
corticostriatal synaptic dysfunction and subsequent neurodegeneration of striatal medium …

Oxidative stress figures prominently in retinal diseases, including diabetic retinopathy, and
glaucoma. Ligands for σ1R, a unique transmembrane protein localized to the endoplasmic …