As the major components of the postsynaptic density of excitatory neuronal synapses, PDZ-
domain-containing scaffold proteins regulate the clustering of surface glutamate receptors …

PDZ domains are highly abundant protein–protein interaction modules and are often found
in multidomain scaffold proteins. PDZ-domain-containing scaffold proteins regulate multiple …

All organisms have to monitor the folding state of cellular proteins precisely. The heat-shock
protein DegP is a protein quality control factor in the bacterial envelope that is involved in …

Cholesterol is known to modulate the physical properties of cell membranes, but its direct
involvement in cellular signaling has not been thoroughly investigated. Here we show that …

The pleckstrin homology [PH] domain is a structural fold found in more than 250 proteins
making it the 11th most common domain in the human proteome. 25% of family members …

The initial reports on pleckstrin homology (PH) domains almost 20years ago described them
as sequence feature of proteins involved in signal transduction processes. Investigated at …

The PDZ domain is a protein–protein interacting module that plays an important role in the
organization of signaling complexes. The recognition of short intrinsically disordered C …

Multiple PDZ domain scaffold protein Par-3 and phosphoinositides (PIPs) are required for
polarity in diverse cell types. We show that the second PDZ domain of Par-3 binds to …

Modular pleckstrin homology (PH) and phospho-tyrosine binding (PTB) domains are present
in a remarkably large number of proteins from yeast to humans. With a common core fold …

PDZ domains are found in many signaling proteins. One of their functions is to provide
scaffolds for forming membrane‐associated protein complexes by binding to the carboxyl …