Obsessive-compulsive disorder is a severe and disabling psychiatric disorder that presents
several challenges for neuroscience. Recent advances in its genetic and developmental …

Adult hippocampal neurogenesis has been implicated in cognitive processes, such as
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …

In many circumstances alternative courses of action and thoughts have to be inhibited to
allow the emergence of goal-directed behavior. However, this has not been the accepted …

Obsessive–compulsive disorder (OCD) is characterized by repetitive thoughts and
behaviours that are experienced as unwanted. Family and twin studies have demonstrated …

Objective: Biomarkers are defined as anatomical, biochemical or physiological traits that are
specific to certain disorders or syndromes. The objective of this paper is to summarise the …

A key criticism of the main diagnostic tool in psychiatry, the Diagnostic and Statistical Manual
of Mental Health Disorders (DSM-IV), is that it lacks a biological footing. In this article, we …

Impulsivity and compulsivity represent useful conceptualizations that involve dissociable
cognitive functions, which are mediated by neuroanatomically and neurochemically distinct …

Obsessive-compulsive disorder (OCD) is a serious and often chronically disabling condition.
The current dominant model of OCD focuses on abnormalities in prefrontal-striatal circuits …

Background A recent hypothesis has suggested that core deficits in goal-directed behavior
in obsessive-compulsive disorder (OCD) are caused by impaired frontostriatal function. We …

Background Deep brain stimulation (DBS) is an emerging treatment for severe obsessive-
compulsive disorder (OCD). We compared the efficacy of ventral capsule/ventral striatal …