DNA, mRNA and microRNA are released and circulate in the blood of cancer patients.
Changes in the levels of circulating nucleic acids have been associated with tumour burden …

DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …

Circulating cell-free DNA (cfDNA) has been suggested as a cancer biomarker. Several
studies assessed the usefulness of quantitative and qualitative tumor-specific alterations of …

In the last years, mortality from breast cancer has declined in western countries as a
consequence of a more widespread screening resulting in earlier detection, as well as an …

Breast cancer is the most prevalent cancer in the world. Currently, the main treatments for
breast cancer are radiotherapy, chemotherapy, targeted therapy and surgery. The treatment …

Circulating tumor DNA (ctDNA) is now being extensively studied as it is a noninvasive “real-
time” biomarker that can provide diagnostic and prognostic information before, during …

Breast cancer is the most common cancer in women worldwide, and resistance to the
current therapeutics, often concurrently, is an increasing clinical challenge. By …

Both appropriate DNA methylation and histone modifications play a crucial role in the
maintenance of normal cell function and cellular identity. In cancerous cells these …

Qualitative and quantitative analysis of circulating cell-free DNA (cfDNA) is an emerging non-
invasive blood biomarker utilized to assess tumor progression and to evaluate prognosis …

Gastrointestinal (GI) cancer represents a major global health problem due to its aggressive
characteristics and poor prognosis. Despite the progress achieved in the development of …