Glycosylation is the most abundant and diverse form of post-translational modification of
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …

Fucose is a 6-deoxy hexose in the l-configuration found in a large variety of different
organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Glycosylation is catalyzed by various glycosyltransferase enzymes which are mostly located
in the Golgi apparatus in cells. These enzymes glycosylate various complex carbohydrates …

Aberrant glycosylation is a universal feature of cancer cells that can impact all steps in
tumour progression from malignant transformation to metastasis and immune evasion. One …

Despite advances in understanding the development and progression of cancer in recent
years, there remains a lack of comprehensive characterization of the cancer glycoproteome …

Summary Programmed cell death 1 (PD-1) is highly expressed on exhausted T cells and
inhibits T cell activation. Antibodies that block the interaction between PD-1 and its ligand …

Protein glycosylation is an important posttranslational process, which regulates protein
folding and functional expression. Studies have shown that abnormal glycosylation in tumor …

Fucosylated carbohydrate structures are involved in a variety of biological and pathological
processes in eukaryotic organisms including tissue development, angiogenesis, fertilization …

Fucosylation is one of the most common modifications involving oligosaccharides on
glycoproteins or glycolipids. Fucosylation comprises the attachment of a fucose residue to N …