Challenges in the development of bioanalytical liquid chromatography–mass spectrometry method with emphasis on fast analysis
L Nováková - Journal of Chromatography A, 2013 - Elsevier
The development of bioanalytical methods has become more and more challenging over the
past years due to very demanding requirements in terms of method reliability, sensitivity …
past years due to very demanding requirements in terms of method reliability, sensitivity …
Atazanavir, alone or in combination with ritonavir, inhibits SARS-CoV-2 replication and proinflammatory cytokine production
N Fintelman-Rodrigues, CQ Sacramento… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is already responsible for
far more deaths than previous pathogenic coronaviruses (CoVs) from 2002 and 2012. The …
far more deaths than previous pathogenic coronaviruses (CoVs) from 2002 and 2012. The …
Current antiviral drugs and their analysis in biological materials–Part II: Antivirals against hepatitis and HIV viruses
L Nováková, J Pavlík, L Chrenková, O Martinec… - … of pharmaceutical and …, 2018 - Elsevier
This review is a Part II of the series aiming to provide comprehensive overview of currently
used antiviral drugs and to show modern approaches to their analysis. While in the Part I …
used antiviral drugs and to show modern approaches to their analysis. While in the Part I …
Characterization of nanodiamond-based anti-HIV drug delivery to the brain
Abstract Human Immunodeficiency Virus Type 1 (HIV-1) remains one of the leading causes
of death worldwide. Present combination antiretroviral therapy has substantially improved …
of death worldwide. Present combination antiretroviral therapy has substantially improved …
CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice
B Bhargavan, SM Woollard, JE McMillan… - Molecular …, 2021 - Springer
Background Neurocognitive impairment is present in 50% of HIV-infected individuals and is
often associated with Alzheimer's Disease (AD)-like brain pathologies, including increased …
often associated with Alzheimer's Disease (AD)-like brain pathologies, including increased …
Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice
Objectives: Long-acting nanoformulated antiretroviral therapy (nanoART) with improved
pharmacokinetics, biodistribution and limited systemic toxicities will likely improve drug …
pharmacokinetics, biodistribution and limited systemic toxicities will likely improve drug …
Antiretroviral solid drug nanoparticles with enhanced oral bioavailability: production, characterization, and in vitro–in vivo correlation
TO McDonald, M Giardiello, P Martin… - Advanced …, 2014 - Wiley Online Library
Nanomedicine strategies have produced many commercial products. However, no orally
dosed HIV nanomedicines are available clinically to patients. Although nanosuspensions of …
dosed HIV nanomedicines are available clinically to patients. Although nanosuspensions of …
Macrophage folate receptor-targeted antiretroviral therapy facilitates drug entry, retention, antiretroviral activities and biodistribution for reduction of human …
P Puligujja, JE McMillan, L Kendrick, T Li… - … , Biology and Medicine, 2013 - Elsevier
Macrophages serve as vehicles for the carriage and delivery of polymer-coated
nanoformulated antiretroviral therapy (nanoART). Although superior to native drug, high …
nanoformulated antiretroviral therapy (nanoART). Although superior to native drug, high …
[HTML][HTML] Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations
P Puligujja, SS Balkundi, LM Kendrick, HM Baldridge… - Biomaterials, 2015 - Elsevier
Long-acting nanoformulated antiretroviral therapy (nanoART) that targets monocyte-
macrophages could improve the drug's half-life and protein-binding capacities while …
macrophages could improve the drug's half-life and protein-binding capacities while …
Preclinical pharmacokinetics and tissue distribution of long-acting nanoformulated antiretroviral therapy
Long-acting injectable nanoformulated antiretroviral therapy (nanoART) was developed with
the explicit goal of improving medicine compliance and for drug targeting of viral tissue …
the explicit goal of improving medicine compliance and for drug targeting of viral tissue …