Acanthamoeba keratitis: an emerging disease gathering importance worldwide?

J Lorenzo-Morales, CM Martín-Navarro… - Trends in …, 2013 - cell.com
Acanthamoeba keratitis (AK) is increasingly being recognized as a severe sight-threatening
ocular infection worldwide. Although contact lens wear is the leading risk factor for AK …

Drug target identification, validation, characterisation and exploitation for treatment of Acanthamoeba (species) infections

CW Roberts, FL Henriquez - Experimental parasitology, 2010 - Elsevier
New more efficacious antimicrobials as required for the treatment of Acanthamoeba
infections as those currently available require arduous treatment regimes, are not always …

[HTML][HTML] Pitavastatin loaded nanoparticles: a suitable ophthalmic treatment for Acanthamoeba Keratitis inducing cell death and autophagy in Acanthamoeba …

I Sifaoui, P Díaz-Rodríguez… - European Journal of …, 2022 - Elsevier
Statins are effective sterol lowering agents with high amoebicidal activity. Nevertheless, due
to their poor aqueous solubility, they remain underused especially in eye drop formulation …

[HTML][HTML] Gongolarones as antiamoeboid chemical scaffold

RL Rodríguez-Expósito… - Biomedicine & …, 2023 - Elsevier
Abstract Free Living Amoeba (FLA) infections caused by Acanthamoeba genus include
chronic nervous system diseases such as Granulomatous Amoebic Encephalitis (GAE), or a …

Programmed cell death in Acanthamoeba castellanii Neff induced by several molecules present in olive leaf extracts

I Sifaoui, A Lopez-Arencibia, CM Martín-Navarro… - PloS one, 2017 - journals.plos.org
Therapy against Acanthamoeba infections such as Granulomatous Amoebic Encephalitis
(GAE) and Acanthamoeba Keratitis (AK), remains as an issue to be solved due to the …

Anti-Acanthamoeba Activity of Brominated Sesquiterpenes from Laurencia johnstonii

S García-Davis, I Sifaoui, M Reyes-Batlle… - Marine drugs, 2018 - mdpi.com
Focused on our interest to develop novel antiparasistic agents, the present study was aimed
to evaluate the biological activity of an extract of Laurencia johnstonii collected in Baja …

Isolation and characterization of Acanthamoeba strains from soil samples in Gran Canaria, Canary Islands, Spain

M Reyes-Batlle, CD Todd, CM Martín-Navarro… - Parasitology …, 2014 - Springer
Abstract Free-living Amoebae of Acanthamoeba genus include non-pathogenic and
pathogenic strains that are currently classified in 18 different genotypes, T1–T18. In this …

In Vitro Activity of Statins against Naegleria fowleri

A Rizo-Liendo, I Sifaoui, M Reyes-Batlle, O Chiboub… - Pathogens, 2019 - mdpi.com
Naegleria fowleri causes a deadly disease called primary amoebic meningoencephalitis
(PAM). Even though PAM is still considered a rare disease, the number of reported cases …

In vitro anti-Acanthamoeba synergistic effect of chlorhexidine and cationic carbosilane dendrimers against both trophozoite and cyst forms

I Heredero-Bermejo, J Sanchez-Nieves… - International journal of …, 2016 - Elsevier
Acanthamoeba sp. are the causative agents of severe illnesses in humans such as
Acanthamoeba keratitis (AK) and granulomatous amoebic encephalitis (GAE). Medical …

Evaluation of the in vitro activity of commercially available moxifloxacin and voriconazole eye-drops against clinical strains of Acanthamoeba

CM Martín-Navarro, A López-Arencibia… - Graefe's Archive for …, 2013 - Springer
Purpose Acanthamoeba is an opportunistic pathogen which is the causal agent of a sight-
threatening ulceration of the cornea known as “Acanthamoeba keratitis”(AK) and, more …