The zebrafish breathes new life into the study of tuberculosis

H Myllymäki, CA Bäuerlein, M Rämet - Frontiers in immunology, 2016 - frontiersin.org
Tuberculosis (TB) is a global health emergency. Up to one-third of the world's population is
infected with Mycobacterium tuberculosis, and the pathogen continues to kill 1.5 million …

Infectious disease models in zebrafish

C Sullivan, MA Matty, D Jurczyszak, KA Gabor… - Methods in cell …, 2017 - Elsevier
In recent years, the zebrafish (Danio rerio) has developed as an important alternative to
mammalian models for the study of hostpathogen interactions. Because they lack a …

Shigella induces epigenetic reprogramming of zebrafish neutrophils

MC Gomes, D Brokatzky, MK Bielecka, FC Wardle… - Science …, 2023 - science.org
Trained immunity is a long-term memory of innate immune cells, generating an improved
response upon reinfection. Shigella is an important human pathogen and inflammatory …

Heat‐inactivated Mycobacterium bovis protects zebrafish against mycobacteriosis

V López, MA Risalde, M Contreras… - Journal of fish …, 2018 - Wiley Online Library
Control of mycobacterial infection constitutes a priority for human and animal health
worldwide. However, effective vaccines are needed for the control of human and animal …

Identification of protective postexposure mycobacterial vaccine antigens using an immunosuppression-based reactivation model in the zebrafish

H Myllymäki, M Niskanen, H Luukinen… - Disease models & …, 2018 - journals.biologists.com
Roughly one third of the human population carries a latent Mycobacterium tuberculosis
infection, with a 5-10% lifetime risk of reactivation to active tuberculosis and further …

Identification of novel antigen candidates for a tuberculosis vaccine in the adult zebrafish (Danio rerio)

H Myllymäki, M Niskanen, KE Oksanen, E Sherwood… - PLoS …, 2017 - journals.plos.org
Tuberculosis (TB) remains a major global health challenge and the development of a better
vaccine takes center stage in fighting the disease. For this purpose, animal models that are …

The impact of genome region of difference 4 (RD4) on mycobacterial virulence and BCG efficacy

H Ru, X Liu, C Lin, J Yang, F Chen, R Sun… - Frontiers in cellular …, 2017 - frontiersin.org
Comparative genome analyses have revealed a number of regions of difference (RD)
among mycobacterial species. The functional consequences of most of these genome …

Boas práticas na criação e manutenção de zebrafish (Danio rerio) em laboratório no Brasil

MT Kütter, LJG Barcellos, RT Boyle, LF Marins… - Ciência Animal …, 2023 - SciELO Brasil
Resumo As Boas Práticas de Laboratório (BPL) são um sistema de controle de qualidade
gerencial que abrange o processo organizacional e as condições sob as quais os estudos …

Antigen identification strategies and preclinical evaluation models for advancing tuberculosis vaccine development

S Chugh, RK Bahal, R Dhiman, R Singh - npj Vaccines, 2024 - nature.com
In its myriad devastating forms, Tuberculosis (TB) has existed for centuries, and humanity is
still affected by it. Mycobacterium tuberculosis (M. tuberculosis), the causative agent of TB …

Good practices in the rearing and maintenance of zebrafish (Danio rerio) in Brazilian laboratories

MT Kütter, LJG Barcellos, RT Boyle, LF Marins… - Ciência Animal …, 2023 - SciELO Brasil
Abstract Good Laboratory Practice (GLP) is a management quality control system that
encompasses the organizational process and conditions under which non-clinical health …