The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …

The Wnt signaling pathway is critically involved in both the development and homeostasis of
tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been …

There were multiple prerequisites to the evolution of multicellular animal life, including the
generation of multiple cell fates (" cellular diversity") and their patterned spatial arrangement …

Polarity establishment, asymmetric division, and acquisition of cell fates are critical steps
during earlydevelopment. In this review, we discuss processes that set up the embryonic …

Morphological asymmetry is a common feature of animal body plans, from shell coiling in
snails to organ placement in humans. The signaling protein Nodal is key for determining this …

Wnt signaling pathways act at multiple locations and developmental stages to specify cell
fate and polarity in vertebrate embryos. A long-standing question is how the same molecular …

Wnt signaling cascade has developed together with multicellularity to orchestrate the
development and homeostasis of complex structures. Wnt pathway components–such as β …

Neurons and oligodendrocytes communicate to regulate oligodendrocyte development and
ensure appropriate axonal myelination. Here, we show that Glycerophosphodiester …

Developmental processes are intrinsically robust so as to preserve a normal-like state in
response to genetic and environmental fluctuations. However, the robustness and potential …

Abstract Prominin-1 (CD133) is a cholesterol-binding membrane glycoprotein selectively
associated with highly curved and prominent membrane structures. It is widely recognized …