Limited understanding of human proteoforms with complex posttranslational modifications
and the underlying mechanisms poses a major obstacle to research on human health and …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

Epigenetic regulators have a crucial effect on gene expression based on their manipulation
of histone modifications. Histone H2AK119 monoubiquitination (H2AK119Ub), a well …

The DNA damage repair regulatory protein RNF168, a monomeric RING-type E3 ligase, has
a crucial role in regulating cell fate and DNA repair by specific and efficient ubiquitination of …

The chemical synthesis of histones with homogeneous modifications is a powerful approach
for quantitatively deciphering the functional crosstalk between different post‐translational …

Nucleosomes are major determinants of eukaryotic genome organization and regulation.
Many studies, incorporating a diversity of experimental approaches, have been focused on …

Histone H2B monoubiquitination in budding yeast is a highly conserved post-translational
modification. It is involved in normal functions of the cells like DNA Repair, RNA Pol II …

The chemical synthesis of homogeneously ubiquitylated histones is a powerful approach to
decipher histone ubiquitylation-dependent epigenetic regulation. Among the various …

Abstract The 2-((2-chloroethyl) amino) ethane-1-thiol (CAET)-based chemical trapping
strategy is a practical tool for mechanistic studies of E3-catalysed ubiquitination. However …

Aims We aimed to investigate the role of Rnf40 in hypertension‐induced cerebrovascular
endothelial barrier dysfunction and cognitive impairment. Methods We employed microarray …