Cancer in the broader sense refers to more than 277 different types of cancer disease.
Scientists have identified different stage of cancers, indicating that several gene mutations …

c-MYC is one of the most essential transcriptional factors, regulating a diverse array of
cellular functions, including proliferation, growth, and apoptosis. Dysregulation of c-MYC is …

Diffuse large B-cell lymphoma (DLBCL) is the most common form of human lymphoma.
Although a number of structural alterations have been associated with the pathogenesis of …

Genomic instability promotes tumorigenesis and can occur through various mechanisms,
including defective segregation of chromosomes or inactivation of DNA mismatch repair …

Background An explosion of research has been done in discovering how human health is
affected by environmental factors. I will discuss the impacts of environmental cancer causing …

Gene-expression profiling has identified 3 major subgroups of diffuse large B-cell lymphoma
(DLBCL): germinal center B-cell-like (GCB), activated B-cell-like (ABC), and primary …

Many malignancies of mature B cells are characterized by chromosomal translocations
involving the immunoglobulin heavy chain (IGH) locus on chromosome 14q32. 3 and result …

Most, if not all, malignancies have recurrent and disease-specific clonal chromosomal
abnormalities, which play a pivotal role in tumor development. These comprise deletions or …

The PR (PRDI-BF1-RIZ) domain zinc finger protein 1 (PRDM1) is a transcription repressor
with a pivotal role in plasma-cell differentiation. We identified clonal inactivating mutations in …

Diffuse large B-cell lymphoma is the most common lymphoma worldwide. Both
morphologically and prognostically it represents a diverse spectrum of disease. Traditional …