Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Kv7 potassium channels regulate excitability in neuronal, sensory, and muscular cells. Here,
we describe their molecular architecture, physiological roles, and involvement in genetically …

The field of mitochondrial ion channels underwent a rapid development during the last
decade, thanks to the molecular identification of some of the nuclear-encoded organelle …

Kv7 channels tune neuronal and cardiomyocyte excitability. In addition to the channel
membrane domain, they also have a unique intracellular C-terminal (CT) domain, bound …

Summary Kv7 (KCNQ) voltage-gated potassium channels control excitability in the brain,
heart, and ear. Calmodulin (CaM) is crucial for Kv7 function, but how this calcium sensor …

Voltage-gated ion channels generate electrical currents that control muscle contraction,
encode neuronal information, and trigger hormonal release. Tissue-specific expression of …

Gating of voltage-dependent cation channels involves three general molecular processes:
voltage sensor activation, sensor-pore coupling, and pore opening. KCNQ1 is a voltage …

Voltage-gated potassium 7.1 (Kv7. 1) channel and KCNE1 protein coassembly forms the
slow potassium current IKS that repolarizes the cardiac action potential. The physiological …

We identified six novel de novo human KCNQ5 variants in children with motor/language
delay, intellectual disability (ID), and/or epilepsy by whole exome sequencing. These …

Rationale: The mutation A341V in the S6 transmembrane segment of KCNQ1, the α-subunit
of the slowly activating delayed-rectifier K+ (IKs) channel, predisposes to a severe long-QT1 …