Cardiac disorders such as acute myocardial infarction, embolism and stroke are primarily
attributed to excessive fibrin accumulation in the blood vessels, usually consequential in …

Thrombosis has threatened human health in past decades. Bacillus nattokinase is a
potential low-cost thrombolytic drug without side-effects and has been introduced into the …

Fibrinolytic enzymes are proteases responsible for cleavage of fibrin mesh in thrombus clots,
which are the primary causative agents in cardiovascular diseases. Developing safe …

With the dramatic increase in mortality of cardiovascular diseases (CVDs) caused by
thrombus, this has sparked an interest in seeking more effective thrombolytic drugs or …

Nattokinase (NK) is an alkaline serine protease with strong thrombolytic activity produced by
Bacillus spp. or Pseudomonas spp. It is a potential therapeutic agent for thrombotic diseases …

Abstract According to the World Health Organization, cardiovascular disease (CVD) has
become a major cause of chronic illness around the globe. It has been reported that soy …

Nattokinase is a potential new thrombolytic drug because of its strong thrombolytic effect,
high safety, and low cost. However, there is no research reporting on bile salt-tolerant …

Abstract Nattokinase (EC 3.4. 21.62) is a profibrinolytic serine protease with a potent fibrin-
degrading activity, and it has been produced by many host strains. Compared to other …

Proteases are one of the largest groups of hydrolytic enzymes constituting about 60% of total
worldwide sales of industrial enzymes due to their wide applications in detergent, leather …

Nattokinase (NK) as a serine protease enzyme has a strong fibrinolytic activity that is found
in bacteria. In comparison to other fibrinolytic enzymes (plasmin, urokinase, and t-PA), NK …