The first mammalian Wnt to be discovered, Wnt-1, was found to be essential for the
development of a large part of the mouse brain over 25 years ago. We have since learned …

Autosomal recessive primary microcephaly (MCPH;“small head syndrome”) is a rare,
heterogeneous disease arising from the decreased production of neurons during brain …

We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the
association between the disorder and chromosomal copy number (CNV) burden. We …

Reappraisal of neuropathological studies suggests that pathological hallmarks of
Alzheimer's disease and Parkinson's disease (PD) spread progressively along predictable …

The efficient generation of striatal neurons from human embryonic stem cells (hESCs) and
induced pluripotent stem cells (hiPSCs) is fundamental for realising their promise in disease …

The maturation and functional characteristics of human induced pluripotent stem cell
(hiPSC)-cortical neurons has not been fully documented. This study developed a phenotypic …

Huntington disease (HD) damages the corticostriatal circuitry in large part by impairing
transport of brain-derived neurotrophic factor (BDNF). We hypothesized that improving …

Neurodegenerative disorders are a major public health problem because of the high
frequency of these diseases. Genome editing with the CRISPR/Cas9 system is making it …

Wnt is a complex signaling pathway involved in the regulation of crucial biological functions
such as development, proliferation, differentiation and migration of cells, mainly stem cells …

Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy. One-third of
patients have drug-refractory seizures and are left with suboptimal therapeutic options such …