Despite increasing evidence of major differences between rodent and human immune and
neurological function, relatively few biomedical studies are performed with human cells. This …

Astrocytes have a central role in brain development and function, and so have gained
increasing attention over the past two decades. Consequently, our knowledge about their …

Multiple sclerosis (MS) is a chronic demyelinating disease of unknown etiology that affects
the CNS. While current therapies are primarily directed against the immune system, the new …

Nowadays, the research on NPC transplantation in neurological disorders is advancing on
two different fronts: on one hand, recent preclinical data are uncovering the molecular basis …

In the last decade, induced pluripotent stem (iPS) cells have revolutionized the utility of
human in vitro models of neurological disease. The iPS-derived and differentiated cells …

Multiple sclerosis (MS) is a chronic inflammatory, autoimmune, and neurodegenerative
disease of the central nervous system (CNS). It is characterized by demyelination and …

Rationale: Demyelination is a major component of white matter injury, characterized by
oligodendrocyte (OL) death and myelin sheath loss, which result in memory loss and …

Cardiovascular diseases hold the highest mortality rate among other illnesses which reveals
the significance of current limitations in common therapies. Three-dimensional (3D) …

Myelination in the central nervous system is the process by which oligodendrocytes form
myelin sheaths around the axons of neurons. Myelination enables neurons to transmit …

Oligodendroglial pathology is central to de‐and dysmyelinating, but also contributes to
neurodegenerative and psychiatric diseases as well as brain injury. The understanding of …