The long road toward COVID-19 herd immunity: vaccine platform technologies and mass immunization strategies

LSF Frederiksen, Y Zhang, C Foged… - Frontiers in …, 2020 - frontiersin.org
There is an urgent need for effective countermeasures against the current emergence and
accelerating expansion of coronavirus disease 2019 (COVID-19), caused by severe acute …

[HTML][HTML] Plant molecular farming for the production of valuable proteins–Critical evaluation of achievements and future challenges

S Schillberg, R Finnern - Journal of plant physiology, 2021 - Elsevier
Recombinant proteins play an important role in many areas of our lives. For example,
recombinant enzymes are used in the food and chemical industries and as high-quality …

Plant-based biopharmaceutical engineering

L Eidenberger, B Kogelmann… - Nature Reviews …, 2023 - nature.com
Plants can be engineered to recombinantly produce high-quality proteins such as
therapeutic proteins and vaccines, also known as molecular farming. Molecular farming can …

Contributions of the international plant science community to the fight against infectious diseases in humans—part 2: Affordable drugs in edible plants for endemic and …

W He, C Baysal, M Lobato Gomez… - Plant biotechnology …, 2021 - Wiley Online Library
The fight against infectious diseases often focuses on epidemics and pandemics, which
demand urgent resources and command attention from the health authorities and media …

Wetting of phase-separated droplets on plant vacuole membranes leads to a competition between tonoplast budding and nanotube formation

H Kusumaatmaja, AI May, M Feeney… - Proceedings of the …, 2021 - National Acad Sciences
Seeds of dicotyledonous plants store proteins in dedicated membrane-bounded organelles
called protein storage vacuoles (PSVs). Formed during seed development through …

Surface-tailored zein nanoparticles: strategies and applications

AM Abdelsalam, A Somaida, AM Ayoub, FM Alsharif… - Pharmaceutics, 2021 - mdpi.com
Plant-derived proteins have emerged as leading candidates in several drug and food
delivery applications in diverse pharmaceutical designs. Zein is considered one of the …

Intracellular trafficking and glycosylation of hydroxyproline-O-glycosylation module in tobacco BY-2 cells is dependent on medium composition and transcriptome …

U Karki, P Perez Sanchez, S Chakraborty, B Dickey… - Scientific Reports, 2023 - nature.com
Expression of recombinant proteins in plant cells with a “designer” hydroxyproline (Hyp)-O-
glycosylated peptide (HypGP), such as tandem repeats of a “Ser-Pro” motif, has been shown …

[HTML][HTML] Plant-made poliovirus vaccines–Safe alternatives for global vaccination

OC Bolaños-Martínez, R Strasser - Frontiers in Plant Science, 2022 - frontiersin.org
Human polioviruses are highly infectious viruses that are spread mainly through the fecal-
oral route. Infection of the central nervous system frequently results in irreversible paralysis …

Microparticles and Nanoparticles from Plants—The Benefits of Bioencapsulation

J Schwestka, E Stoger - Vaccines, 2021 - mdpi.com
The efficacy of drugs and vaccines depends on their stability and ability to interact with their
targets in vivo. Many drugs benefit from encapsulation, which protects them from harsh …

[HTML][HTML] Generation of multi-layered protein bodies in N. benthamiana for the encapsulation of vaccine antigens

J Schwestka, L Zeh, M Tschofen, F Schubert… - Frontiers in Plant …, 2023 - frontiersin.org
The ability of plants to assemble particulate structures such as virus-like particles and
protein storage organelles allows the direct bioencapsulation of recombinant proteins during …