Microtubules control cell architecture by serving as a scaffold for intracellular transport,
signaling, and organelle positioning. Microtubules are intrinsically polarized, and their …

Microtubules are core components of the cytoskeleton and serve as tracks for motor protein–
based intracellular transport. Microtubule networks are highly diverse across different cell …

Inappropriate activation of the Hedgehog (Hh) signaling pathway has been implicated in a
diverse spectrum of cancers, and its pharmacological blockade has emerged as an anti …

Tubulin dimers assemble into dynamic microtubules, which are used by molecular motors as
tracks for intracellular transport. Organization and dynamics of the microtubule network are …

Kinesin-1, the founding member of the kinesin superfamily of proteins, is known to use only
a subset of microtubules for transport in living cells. This biased use of microtubules is …

Kinesin-1 is a nanoscale molecular motor that walks towards the fast-growing (plus) ends of
microtubules, hauling molecular cargo to specific reaction sites in cells. Kinesin-driven …

Cells are the elementary units of living organisms, which are able to carry out many vital
functions. These functions rely on active processes on a microscopic scale. Therefore, they …

Polarized transport in neurons is fundamental for the formation of neuronal circuitry. A motor
domain–containing truncated KIF5 (a kinesin-1) recognizes axonal microtubules, which are …

Kinesins drive the transport of cellular cargoes as they walk along microtubule tracks;
however, recent work has suggested that the physical act of kinesins walking along …

Axons are the slender, cable-like, up to meter-long projections of neurons that electrically
wire our brains and bodies. In spite of their challenging morphology, they usually need to be …