Adipogenesis: a complex interplay of multiple molecular determinants and pathways
The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …
Transcriptional and epigenomic regulation of adipogenesis
Understanding adipogenesis, the process of adipocyte development, may provide new ways
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …
[HTML][HTML] Chemical biology of protein arginine modifications in epigenetic regulation
J Fuhrmann, KW Clancy, PR Thompson - Chemical reviews, 2015 - ACS Publications
Post-translational modifications (PTMs) of histone proteins are a hallmark of epigenetic
regulation. They provide a mechanism to modulate chromatin structure and constitute the …
regulation. They provide a mechanism to modulate chromatin structure and constitute the …
[HTML][HTML] Protein arginine methyltransferase 5 (PRMT5) dysregulation in cancer
Protein arginine methyltransferases (PRMTs) are known for their ability to catalyze
methylation of specific arginine residues in a wide variety of cellular proteins, which are …
methylation of specific arginine residues in a wide variety of cellular proteins, which are …
Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth
Abstract Protein arginine methyltransferase 5 (PRMT5) is an emerging epigenetic enzyme
that mainly represses transcription of target genes via symmetric dimethylation of arginine …
that mainly represses transcription of target genes via symmetric dimethylation of arginine …
Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation
L Alinari, KV Mahasenan, F Yan… - Blood, The Journal …, 2015 - ashpublications.org
Epigenetic events that are essential drivers of lymphocyte transformation remain
incompletely characterized. We used models of Epstein-Barr virus (EBV)–induced B-cell …
incompletely characterized. We used models of Epstein-Barr virus (EBV)–induced B-cell …
The structure and functions of PRMT5 in human diseases
A Motolani, M Martin, M Sun, T Lu - Life, 2021 - mdpi.com
Since the discovery of protein arginine methyltransferase 5 (PRMT5) and the resolution of its
structure, an increasing number of papers have investigated and delineated the structural …
structure, an increasing number of papers have investigated and delineated the structural …
The two faces of reactive oxygen species (ROS) in adipocyte function and dysfunction
White adipose tissue (WAT) is actively involved in the regulation of whole-body energy
homeostasis via storage/release of lipids and adipokine secretion. Current research links …
homeostasis via storage/release of lipids and adipokine secretion. Current research links …
[HTML][HTML] Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3
B Zhang, S Dong, R Zhu, C Hu, J Hou, Y Li, Q Zhao… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Protein arginine methyltransferases (PRMTs) plays critical roles in cancer. PRMT5 has been
implicated in several types of tumors. However, the role of PRMT5 in cancer development …
implicated in several types of tumors. However, the role of PRMT5 in cancer development …
Epigenetic regulation of adipogenesis in development of metabolic syndrome
Obesity is one of the biggest public health concerns identified by an increase in adipose
tissue mass as a result of adipocyte hypertrophy and hyperplasia. Pertaining to the …
tissue mass as a result of adipocyte hypertrophy and hyperplasia. Pertaining to the …