Serotonin Receptors in Myocardial Infarction: Friend or Foe?

FS Bahr, M Ricke-Hoch, E Ponimaskin… - ACS Chemical …, 2024 - ACS Publications
Acute myocardial infarction (AMI) is one of the leading causes of death worldwide and
treatment costs pose a major burden on the global health care system. Despite the variety of …

Effects of naringin on oxidative stress, inflammation, some reproductive parameters, and apoptosis in acrylamide‐induced testis toxicity in rat

E Sengul, V Gelen, S Yildirim, İ Cinar… - Environmental …, 2023 - Wiley Online Library
Acrylamide (ACR) is used in many fields such as cosmetics, paper, and textile industries. It
also occurs at very high temperatures in some foods. Gonadotoxic effects of ACR have been …

In vivo and in vitro cardioprotective effect of gossypin against isoproterenol-induced myocardial infarction injury

I Cinar, M Yayla, T Tavaci, E Toktay, RA Ugan… - Cardiovascular …, 2022 - Springer
The aim of the study was to examine the protective effects and possible mechanism of
gossypin against isoproterenol (ISO)-mediated myocardial damage in vivo and H9c2 cell …

Effects of tocilizumab and dexamethasone on the downregulation of proinflammatory cytokines and upregulation of antioxidants in the lungs in oleic acid-induced …

F Terzi, B Demirci, İ Çınar, M Alhilal, HS Erol - Respiratory research, 2022 - Springer
Background Acute respiratory distress syndrome (ARDS) is a life-threatening disease
caused by the induction of inflammatory cytokines and chemokines in the lungs. There is a …

Novel therapeutic approaches targeting 5-HT7 receptors outside the central nervous system

M Kilic, Z Karakoy, H Halici, E Cadirci… - Journal of Receptors …, 2025 - Taylor & Francis
Abstract Serotonin (5-HT) is a neurotransmitter found throughout the human body that
regulates many physiological events arising from the brain and central nervous system …

Selenium reduces acrylamide‐induced testicular toxicity in rats by regulating HSD17B1, StAR, and CYP17A1 expression, oxidative stress, inflammation, apoptosis …

S Yildirim, E Sengul, EH Aksu, İ Cinar… - Environmental …, 2024 - Wiley Online Library
This study investigated the effects of Selenium (Se) on testis toxicity induced by Acrylamide
(ACR) in rats. In our study, 50 male adult rats were used, and the rats were divided into five …

Evaluation of rosmarinic acid against myocardial infarction in maternally separated rats

H Verma, A Bhattacharjee, N Shivavedi… - Naunyn-Schmiedeberg's …, 2022 - Springer
Depression and coronary heart diseases are the common comorbid disorder affecting
humans globally. The present study evaluated the effectiveness of rosmarinic acid (RA) …

5-HT7 receptors as a new target for prostate cancer physiopathology and treatment: an experimental study on PC-3 cells and FFPE tissues

I Cinar, B Sirin, Z Halici, SS Palabiyik-Yucelik… - Naunyn-Schmiedeberg's …, 2021 - Springer
Prostate cancer (PCa) is one of the most common types of cancer seen among men
worldwide. Previous studies have demonstrated that serotonin regulates cell proliferation …

Mitigation of Acute Hepatotoxicity Induced by Cadmium Through Morin: Modulation of Oxidative and Pro-apoptotic Endoplasmic Reticulum Stress and Inflammatory …

E Sengul, S Yildirim, İ Cinar, S Tekin, Y Dag… - … Trace Element Research, 2024 - Springer
Cadmium (Cd) is a toxic heavy metal with significant environmental health hazards. It enters
the body through various routes with tissue accumulation. The relatively longer half-life with …

Determination of anti-cancer effects of Nigella sativa seed oil on MCF7 breast and AGS gastric cancer cells

İ Çınar, B Gıdık, E Dirican - Molecular Biology Reports, 2024 - Springer
Background This study aimed to investigate the cytotoxic, apoptotic, invasion, metastasis,
and heat shock proteins (HSPs) effects of N. sativa oil on breast and gastric cancer cells …