Nowadays, about 150 natural products comprising an allenic or cumulenic structure are
known. The chemistry of these compounds has turned out to be a very attractive and prolific …

Covering: up to August 2015 Alkaloids account for some of the most beautiful and
biologically active natural products. Although they are usually classified along biosynthetic …

Amphibian skin has provided a wide range of biologically active alkaloids. During the past
30 years, over 400 alkaloids of over 20 structural classes have been detected. These …

Acetylcholine receptors were initially defined as nicotinic or muscarinic, based on selective
activation by two natural products, nicotine and muscarine. Several further nicotinic agonists …

The binding site for an open-channel blocker, QX-222, at mouse muscle nicotinic
acetylcholine receptors was probed using site-directed mutagenesis, oocyte expression …

Publisher Summary Nicotine acts on many transmitter systems in different parts of the brain
to promote transmitter release, and these modulatory actions may underlie some of the …

The unique structural architecture of the orthogonal cumulative π-system in allenes has
garnered the attention of synthetic chemists for over a century. 1 From a general reactivity …

Chemistry in a biomedical institute has an imperative to have “the potential to have an
impact on biomedical research”. Thus, during my career of over 40 years at the National …

A remarkably diverse array of biologically active compounds occurs in amphibian skin [1].
These include biogenic amines and derivatives thereof, peptides, proteins, bufadienolides …

Thierry Heidmann, Robert E. Oswald, and Jean-PierreChangeux* abstract: A vast series of
compounds, different from the typical nicotinic antagonists, block in a noncompetitive …