A quaternary carbon bears four other carbon substituents or combination of four non-
hydrogen substituents at four vertices of a tetrahedron. The spirocyclic quaternary carbon …

G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors in the
genome and the most successful family of targets of FDA-approved drugs. New frontiers in …

Small molecule neurotensin receptor 1 (NTSR1) agonists have been pursued for more than
40 years as potential therapeutics for psychiatric disorders, including drug addiction. Clinical …

The review covers various aspects of fluorinated cycloalkyl (C3− C7) building blocks for drug
discovery, including their synthesis, key physicochemical properties, and biological and …

The NTSR1 neurotensin receptor (NTSR1) is a G protein-coupled receptor (GPCR) found in
the brain and peripheral tissues with neurotensin (NTS) being its endogenous peptide …

The neurotensin system spans across the central nervous system, to the enteric nervous
system (gut), and the periphery to govern behaviors and physiological responses that tune …

Abstract “Molecular Glues” are defined as small molecules that can either be endogenous or
synthetic which promote interactions between proteins at their interface. Allosteric …

The small peptide neurotensin (Nts) is implicated in myriad processes including analgesia,
thermoregulation, reward, arousal, blood pressure, and modulation of feeding and body …

Using a discrete, intracellular 19F nuclear magnetic resonance (NMR) probe on
transmembrane helix 6 of the neurotensin receptor 1 (NTS1), we aim to understand how …

Abstract The neurotensin receptor 1 (NTS1) is a G protein-coupled receptor (GPCR) with
promise as a drug target for the treatment of pain, schizophrenia, obesity, addiction, and …