Tumor metastasis and recurrence is one of the biggest problems in curing cancers. Due to
the difficulty in complete removal of the primary tumor in traditional surgeries and the poor …

In recent years, the CRISPR/Cas9-based gene-editing techniques have been well
developed and applied widely in several aspects of research in the biological sciences, in …

CRISPR-Cas provides bacteria and archaea with immunity against invading phages and
foreign plasmid DNA and has been successfully adapted for gene editing in a variety of …

The occurrence of microorganisms has been confirmed in the tumor microenvironment
(TME) of many different organs. Microorganisms (eg, phage, virus, bacteria, fungi, and …

More than a year has passed since the beginning of the 2019 novel coronavirus diseases
(COVID-19) pandemic which has created massive problems globally affecting all aspects of …

Clustered regularly interspaced short palindromic repeats (CRISPR) systems are a set of
versatile gene-editing toolkit that perform diverse revolutionary functions in various fields of …

Viral diseases have emerged as a serious threat to humanity and as a leading cause of
morbidity worldwide. Many viral diagnostic methods and antiviral therapies have been …

Anti-metastatic therapeutics commonly use those compounds that recognize the biomarkers
involved in different signaling pathways of cancer cell metastasis, including tumor …

In standard uses of CRISPR/Cas9 technology, the cutting of genomes and their efficient
repair are considered to go hand-in-hand to achieve desired genetic changes. This includes …

The engineering of viral genomes facilitates both fundamental and applied research on
viruses. However, the multiloci manipulation of DNAs of viruses with large DNA genomes …