With a global tally of more than 500 million cases of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections to date, there are growing concerns about the post …

SARS-CoV-2-specific T cell response has been proven essential for viral clearance, COVID-
19 outcome and long-term memory. Impaired early T cell-driven immunity leads to a severe …

The proliferation of single-cell multimodal sequencing technologies has enabled us to
understand cellular heterogeneity with multiple views, providing novel and actionable …

This narrative review provides an overview of the evolving significance of lymphopenia in
sepsis, emphasizing its critical function in this complex and heterogeneous disease. We …

Endometriosis is defined as ectopic endometrial tissues dispersed outside the endometrium.
This can cause disruption in hormonal and immunological processes, which may increase …

The pandemic of coronavirus disease 2019 (COVID-19) has been the foremost modern
global public health challenge. The airway is the primary target in severe acute respiratory …

Ex vivo modification of T cells with exogenous cargo is a common prerequisite for the
development of T cell therapies, such as chimeric antigen receptor therapy. Despite the …

Background: T-cell responses can be protective or detrimental during severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, the underlying …

Severe inflammatory diseases, including sepsis, are characterized by an impaired host
adaptive and innate immunity which results in immunosuppression, responsible for …

The thymus, where T lymphocytes develop and mature, is sensitive to insults such as tissue
ischemia or injury. The insults can cause thymic atrophy and compromise T-cell …