While progress in enantioselective C–H functionalization has been accomplished by
employing 4d and 5d transition metal-based catalysts, the rapid depletion of these metals in …

Significant progress has been made in recent years in the use of AI and Machine Learning
(ML) for catalyst discovery and optimisation. The effectiveness of ML and data science …

Metal‐catalyzed asymmetric C− H bond annulation strategy offers a versatile platform,
allowing the construction of complex P‐chiral molecules through atom‐and step‐economical …

The atroposelective direct C–H alkylation of heterobiaryls with simple alkenes represents a
challenging and underexplored frontier. Herein we report an iridium (I)-catalyzed …

The assembly of chiral molecules with multiple stereogenic elements is challenging, and,
despite of indisputable advances, largely limited to toxic, cost-intensive and precious metal …

The catalytic asymmetric construction of axially chiral C–N atropisomers remains a
formidable challenge due to their low rotational barriers and is largely reliant on toxic, cost …

Artificial intelligence (AI) is driving a revolution in chemistry, reshaping the landscape of
molecular design. This review explores AI's pivotal roles in the field of organic synthesis …

An electrooxidative reconstruction of the indole core under ambient conditions is reported,
resulting in the construction of tryptanthrins. This electrochemical strategy simplifies …

In recent years, enantioselective electrocatalysis has surfaced as an increasingly‐effective
platform for sustainable molecular synthesis. Despite indisputable progress, strategies that …

Advances in understanding the mechanisms of homogeneous nickel catalysis has led to a
remarkable progress in this field. However, the discovery of active catalysts is still largely …