Objectives To estimate the prevalence of two most common and mutually exclusive− 124 C>
T and− 146 C> T TERT promoter mutations in HNSCC and analyse their prognostic role …

Simple Summary The expression of the telomerase reverse transcriptase (TERT) gene is
commonly repressed in terminally differentiated somatic cells and becomes reactivated in …

Abstract Introduction: Persistence of HIV-1, causing chronic immune activation, is a key
determinant of premature senescence. Early antiretroviral therapy (ART) has been …

Background Colorectal cancer is one of most common tumors in developed countries and,
despite improvements in treatment and diagnosis, mortality rate of patients remains high …

Objective To date, no useful prognostic biomarker exists for patients with oral squamous cell
carcinoma (OCSCC), a tumour with uncertain biological behaviour and subsequent …

A growing body of evidence indicates that telomere dysfunction is a biological marker of
progression in several types of cancer. However, the association between head and neck …

Mucinous cystic neoplasm (MCN) is one of the precursor lesions of pancreatic ductal
adenocarcinoma and intrahepatic cholangiocarcinoma. The aim of this study is to examine …

目的探讨circ_0000263 对HeLa 细胞活性, 凋亡, 端粒酶活性以及放射敏感性的影响及其分子
机制. 方法采用实时荧光定量聚合酶链反应检测circ_0000263 和miR-338-3p mRNA 表达水平 …

Importunate high-risk HPV (HR-HPV) infection is the most common trigger for the cervical
carcinogenesis process. In this respect, the presence of cancer can be imputed to telomere …

Human oncoviruses are able to subvert telomerase function in cancer cells through multiple
strategies. The activity of the catalytic subunit of telomerase (TERT) is universally enhanced …