Bacteriophages as weapons against bacterial biofilms in the food industry

D Gutiérrez, L Rodríguez-Rubio, B Martínez… - Frontiers in …, 2016 - frontiersin.org
Microbiological contamination in the food industry is often attributed to the presence of
biofilms in processing plants. Bacterial biofilms are complex communities of bacteria …

In vitro techniques and measurements of phage characteristics that are important for phage therapy success

T Glonti, JP Pirnay - Viruses, 2022 - mdpi.com
Validated methods for phage selection, host range expansion, and lytic activity
determination are indispensable for maximizing phage therapy outcomes. In this review, we …

Analysis of the virome associated to grapevine downy mildew lesions reveals new mycovirus lineages

M Chiapello, J Rodríguez-Romero, MA Ayllón… - Virus …, 2020 - academic.oup.com
The obligatory biotrophic oomycetes Plasmopara viticola is the causal agent of downy
mildew, a destructive disease of grapevine worldwide. So far, chemical fungicides are …

Bacteriophage procurement for therapeutic purposes

B Weber-Dąbrowska, E Jończyk-Matysiak… - Frontiers in …, 2016 - frontiersin.org
Bacteriophages (phages), discovered 100 years ago, are able to infect and destroy only
bacterial cells. In the current crisis of antibiotic efficacy, phage therapy is considered as a …

Targeting Enterococcus faecalis biofilms with phage therapy

L Khalifa, Y Brosh, D Gelman… - Applied and …, 2015 - Am Soc Microbiol
Phage therapy has been proven to be more effective, in some cases, than conventional
antibiotics, especially regarding multidrug-resistant biofilm infections. The objective here …

Two phages, phiIPLA-RODI and phiIPLA-C1C, lyse mono-and dual-species staphylococcal biofilms

D Gutiérrez, D Vandenheuvel, B Martínez… - Applied and …, 2015 - Am Soc Microbiol
Phage therapy is a promising option for fighting against staphylococcal infections. Two lytic
phages, vB_SauM_phiIPLA-RODI (phiIPLA-RODI) and vB_SepM_phiIPLA-C1C (phiIPLA …

Optimization of phage-antibiotic combinations against Staphylococcus aureus biofilms

R Kebriaei, SM Lehman, RM Shah… - Microbiology …, 2023 - Am Soc Microbiol
Phage therapy has gained attention due to the spread of antibiotic-resistant bacteria and
narrow pipeline of novel antibiotics. Phage cocktails are hypothesized to slow the overall …

Bacteriophage therapy against ESKAPE bacterial pathogens: Current status, strategies, challenges, and future scope

M Kulshrestha, M Tiwari, V Tiwari - Microbial pathogenesis, 2024 - Elsevier
The ESKAPE pathogens are the primary threat due to their constant spread of drug
resistance worldwide. These pathogens are also regarded as opportunistic pathogens and …

A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections

MK Kim, Q Chen, A Echterhof, N Pennetzdorfer… - Nature …, 2024 - nature.com
Bacteriophage (phage) therapy is a promising therapeutic modality for multidrug-resistant
bacterial infections, but its application is mainly limited to personalized therapy due to the …

The virulence index: a metric for quantitative analysis of phage virulence

ZJ Storms, MR Teel, K Mercurio, D Sauvageau - Phage, 2020 - liebertpub.com
Background: One of the main challenges in developing phage therapy and manufacturing
phage products is the reliable evaluation of their efficacy, performance, and quality. Since …