Proteins are “social molecules.” Recent experimental evidence supports the notion that
large protein aggregates, known as biomolecular condensates, affect structurally and …

Structural information on protein–protein interactions (PPIs) is essential for improved
understanding of regulatory interactome networks that confer various physiological and …

Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous
macromolecular networks on a proteome scale, but current methods are experimentally …

Intraflagellar transport (IFT) is a conserved process of cargo transport in cilia that is essential
for development and homeostasis in organisms ranging from algae to vertebrates. In …

Co-fractionation mass spectrometry (CF-MS) uses biochemical fractionation to isolate and
characterize macromolecular complexes from cellular lysates without the need for affinity …

Motile cilia are ancient, evolutionarily conserved organelles whose dysfunction underlies
motile ciliopathies, a broad class of human diseases. Motile cilia contain myriad different …

Proteomics technologies are continually advancing, providing opportunities to develop
stronger and more robust protein interaction networks (PINs). In part, this is due to the ever …

Red blood cells (RBCs)(erythrocytes) are the simplest primary human cells, lacking nuclei
and major organelles and instead employing about a thousand proteins to dynamically …

The chemical complexity of metabolomes goes hand in hand with their functional diversity.
Small molecules have many essential roles, many of which are executed by binding and …

Human mitochondrial (mt) protein assemblies are vital for neuronal and brain function, and
their alteration contributes to many human disorders, eg, neurodegenerative diseases …