Antimalarial drugs have played a mainstream role in controlling the spread of malaria
through the treatment of patients infected with the plasmodial parasites and controlling its …

Abstract Design of tubulin inhibitors as anticancer drugs dynamically developed over the
past 20 years. The modern arsenal of potential tubulin-targeting anticancer agents is …

The continued emergence of resistance to front-line antimalarial treatments is of great
concern. Therefore, new compounds that potentially have a novel target in various …

A novel series of antimalarial benzimidazole derivatives incorporating phenolic Mannich
base side chains at the C2 position, which possess dual asexual blood and sexual stage …

Curcumin has been widely investigated for its myriad cellular effects resulting in reduced
proliferation of various eukaryotic cells including cancer cells and the human malaria …

Constant emergence of drug-resistant Plasmodium falciparum warrants urgent need for
effective and inexpensive drugs. Herein, phthalimide (Pht) analogs possessing the bioactive …

Background: Parasitic diseases including malaria, leishmaniasis and schistosomiasis take a
terrible toll of human life, health and productivity, especially in tropical and subtropical …

We report the synthesis, characterization, and cytotoxic and antimalarial activity of ferrocene–
indole hybrids 8–14. The 2-phenylindole scaffold was chosen because of its potent …

Microtubules are cytoskeletal filaments essential for many cellular processes, including
establishment and maintenance of polarity, intracellular transport, division and migration. In …

Plasmodium falciparum is named for the crescent or falciform shape it adopts when
preparing to undergo transfer to a mosquito vector. By contrast, gametocytes of the other …