Background Improving diversity in clinical trials is essential in order to produce
generalizable results. Although the importance of representation has become increasingly …

The United States has long made substantial investments in clinical research with the goal
of improving the health and well-being of our nation. There is no doubt that these …

Importance Older patients and those with comorbidities who are infected with SARS-CoV-2
may be at increased risk of hospitalization and death. Sotrovimab is a neutralizing antibody …

Background Systemic progress in improving trial representation is uncertain, and previous
analyses of minority trial participation have been limited to small cohorts with limited …

Summary Background Randomised controlled trials (RCTs) inform prescription guidelines,
but stringent eligibility criteria exclude individuals with vulnerable characteristics, which we …

Longstanding social and economic inequities elevate health risks and vulnerabilities for
Black, Indigenous and People of Color (BIPOC) communities. Engagement of BIPOC …

Importance Since the onset of the COVID-19 pandemic, there have been calls for COVID-19
clinical trials to be fully representative of all demographic groups. However, limited evidence …

Women, and specifically women of color, are underrepresented in clinical trials, limiting
biological understanding and contributing to health inequities and social injustice. Analyses …

Introduction Several vaccines against severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) have been developed since the inception of the coronavirus disease 2019 …

Importance Non-Hispanic Black individuals experience a higher burden of COVID-19 than
the general population; hence, there is an urgent need to characterize the unique clinical …