The increasing availability of biomedical data from large biobanks, electronic health records,
medical imaging, wearable and ambient biosensors, and the lower cost of genome and …

Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …

Abstract The Animal QTLdb (https://www. animalgenome. org/QTLdb) and CorrDB
(https://www. animalgenome. org/CorrDB) are unique resources for livestock animal …

Polygenic risk scores (PRS) estimate an individual's genetic likelihood of complex traits and
diseases by aggregating information across multiple genetic variants identified from genome …

Cell type-and differentiation-specific gene expression is precisely controlled by genomic non-
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …

Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …

Studies of the human microbiome share both technical and conceptual similarities with
genome-wide association studies and genetic epidemiology. However, the microbiome has …

Genome-wide association studies and functional genomics studies have linked specific cell
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …

DNA–protein interactions mediate physiologic gene regulation and may be altered by DNA
variants linked to polygenic disease. To enhance the speed and signal-to-noise ratio (SNR) …

Background Genetic influences are ubiquitous as virtually all phenotypes and most
exposures typically classified as environmental have been found to be heritable. A …