Polyoxometalates (POMs) are a kind of inorganic cluster metal complex with various
biological activities, such as anti-Alzheimer's disease, antibacterial, anti-cancer, anti …

Histone deacetylase (HDAC) inhibitors have gained attention over the past three decades
because of their potential in the treatment of different diseases including various forms of …

In this study, the methanolic and infusion extracts of two species, Thymbra capitata and
Thymus sipyleus subsp. rosulans, were tested for their chemical composition and biological …

Legionella pneumophila replicates intracellularly by secreting effectors via a type IV
secretion system. One of these effectors is a eukaryotic methyltransferase (RomA) that …

Arum elongatum (Araceae) is widely used traditionally for the treatment of abdominal pain,
arterial hypertension, diabetes mellitus, rheumatism and hemorrhoids. This study …

The members of the genus Hypericum have great potential to develop functional uses in
nutraceutical and pharmaceutical applications. With this in mind, we aimed to determine the …

Background/Aim: Papillary Thyroid Cancer (PTC) is the most common type of endocrine
malignancy. Although PTC has an excellent prognosis, the recurrent or metastatic disease …

Histone deacetylases (HDACs) are implicated in the pathology of various cancers, and their
pharmacological blockade has proven to be promising in reversing the malignant …

Abstract Human histone deacetylase 6 (HDAC6) has been shown to play a major role in
oncogenic cell transformation via deacetylation of α-tubulin, making it a viable target of …

Herein we present the synthesis and characterization of a novel chemical series of tadalafil
analogues that display different pharmacological profiles. Compounds that have the 6R …