Synthetic biology: bottom-up assembly of molecular systems

S Hirschi, TR Ward, WP Meier, DJ Müller… - Chemical …, 2022 - ACS Publications
The bottom-up assembly of biological and chemical components opens exciting
opportunities to engineer artificial vesicular systems for applications with previously unmet …

Bioinspired polymer vesicles and membranes for biological and medical applications

CG Palivan, R Goers, A Najer, X Zhang, A Car… - Chemical society …, 2016 - pubs.rsc.org
Biological membranes play an essential role in living organisms by providing stable and
functional compartments, preserving cell architecture, whilst supporting signalling and …

Sequential bottom-up assembly of mechanically stabilized synthetic cells by microfluidics

M Weiss, JP Frohnmayer, LT Benk, B Haller… - Nature materials, 2018 - nature.com
Compartments for the spatially and temporally controlled assembly of biological processes
are essential towards cellular life. Synthetic mimics of cellular compartments based on lipid …

Polymersomes for therapeutic delivery of protein and nucleic acid macromolecules: from design to therapeutic applications

S Iqbal, M Blenner, A Alexander-Bryant… - …, 2020 - ACS Publications
Macromolecule-based therapeutic agents, particularly proteins, antigens, monoclonal
antibodies, transcription factors, nucleic acids, and gene editing enzymes, have the potential …

Polymersomes in nanomedicine-A review

X Zhang, P Zhang - Current Nanoscience, 2017 - ingentaconnect.com
Background: The worldwide medicine research is dedicated towards improvement of
patients' health and diseased state. The use of nanotechnology is an upcoming area which …

Wavelength-selective light-responsive DASA-functionalized polymersome nanoreactors

O Rifaie-Graham, S Ulrich… - Journal of the …, 2018 - ACS Publications
Transient activation of biochemical reactions by visible light and subsequent return to the
inactive state in the absence of light is an essential feature of the biochemical processes in …

Biocatalytic self-assembled synthetic vesicles and coacervates: From single compartment to artificial cells

D Gaur, NC Dubey, BP Tripathi - Advances in Colloid and Interface Science, 2022 - Elsevier
Compartmentalization is an intrinsic feature of living cells that allows spatiotemporal control
over the biochemical pathways expressed in them. Over the years, a library of …

[HTML][HTML] Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment

T Einfalt, D Witzigmann, C Edlinger, S Sieber… - Nature …, 2018 - nature.com
Despite tremendous efforts to develop stimuli-responsive enzyme delivery systems, their
efficacy has been mostly limited to in vitro applications. Here we introduce, by using an …

Engineering polymersomes for diagnostics and therapy

J Leong, JY Teo, VK Aakalu, YY Yang… - Advanced healthcare …, 2018 - Wiley Online Library
Engineered polymer vesicles, termed as polymersomes, confer a flexibility to control their
structure, properties, and functionality. Self‐assembly of amphiphilic copolymers leads to …

Polymer–lipid hybrid materials

YK Go, C Leal - Chemical reviews, 2021 - ACS Publications
Hierarchic self-assembly underpins much of the form and function seen in synthetic or
biological soft materials. Lipids are paramount examples, building themselves in nature or …