Decades of research has recognized a solid role for Pim kinases in lymphoproliferative
disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling …

Kaposi sarcoma (KS) herpesvirus (KSHV), also known as human herpesvirus 8, is the
causal agent of KS but is also pathogenetically related to several lymphoproliferative …

Rho GTPases contribute to multiple cellular processes that could affect cancer progression,
including cytoskeletal dynamics, cell cycle progression, transcriptional regulation, cell …

The identification as cooperating targets of Proviral Integrations of Moloney virus in murine
lymphomas suggested early on that PIM serine/threonine kinases play an important role in …

To mount an optimum immune response, mature B lymphocytes can change the class of
expressed antibody from IgM to IgG, IgA, or IgE through a recombination/deletion process …

Genomics has provided a lever to pry open lymphoid cells and examine their regulatory
biology. The large body of available gene expression data has also allowed us to define the …

Despite the introduction of highly active antiretroviral therapy or combination antiretroviral
therapy (HAART and cART, respectively) patients infected with HIV might develop certain …

The Rho GTPases are influential regulators of signalling pathways that control vital cellular
processes such as cytoskeletal dynamics, gene transcription, cell cycle progression and cell …

We have addressed whether aberrant ongoing hypermutation can be detected in the proto-
oncogenes PIM1, c-MYC, RhoH/TTF, PAX5, and the tumor-suppressor gene CD95 in …

Somatic hypermutation (SHM) targets primarily the immunoglobulin variable region (IgV)
genes in germinal center (GC) B cells, thereby allowing antibody affinity maturation. A …