The discovery of the genetic causes of syndromic autism spectrum disorders and intellectual
disabilities has greatly informed our understanding of the molecular pathways critical for …

The traditional role of microglia has been in brain infection and disease, phagocytosing
debris and secreting factors to modify disease progression. Recent evidence extends their …

Since it was first described by the German anatomist and histologist, Joseph Hugo Vincenz
Disse, the structure and functions of the space of Disse, a thin perisinusoidal area between …

Rett syndrome (RTT) is an X-linked neurodevelopmental disease predominantly caused by
mutations of the methyl-CpG-binding protein 2 (MeCP2) gene. Generally, RTT has been …

The mechanisms of neuro-genetic disorders have been mostly investigated in the brain,
however, for some pathologies, transcriptomic analysis in multiple tissues represent an …

Rett syndrome (RTT) is a rare, X-linked neurodevelopmental disorder typically affecting
females, resulting in a range of symptoms including autistic features, intellectual impairment …

Objectives Rett syndrome (RTT) is an X-linked autism spectrum disorder caused by
mutations in the MeCP2 gene in the great majority of cases. Evidence suggests a potential …

Astrocyte activation in the spinal dorsal horn may play an important role in the development
of chronic neuropathic pain, but the mechanisms involved in astrocyte activation and their …

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder usually caused by
mutations in methyl-CpG-binding protein 2 (MeCP2). RTT is typified by apparently normal …

An intriguing finding about the gene encoding methyl-CpG binding protein 2 (MeCP2) is that
the loss-of-function mutations cause Rett syndrome and duplication (gain-of-function) of …