The CNS is endowed with an elaborated response repertoire termed'neuroinflammation',
which enables it to cope with pathogens, toxins, traumata and degeneration. On the basis of …

Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

Abstract The K+-Cl− cotransporter KCC2 is responsible for maintaining low Cl−
concentration in neurons of the central nervous system (CNS), which is essential for …

Microglia‐neuron interactions play a crucial role in several neurological disorders
characterized by altered neural network excitability, such as epilepsy and neuropathic pain …

The brain derived neurotrophic factor (BDNF) is a crucial neuromodulator in pain
transmission both in peripheral and central nervous system (CNS). Despite evidence of a …

Brain derived neurotrophic factor (BDNF) is well recognized for its neuroprotective functions,
via activation of its high affinity receptor, tropomysin related kinase B (TrkB). In addition …

A brief comparison of the pathophysiology of inflammatory ve... : Current Opinion in
Anesthesiology A brief comparison of the pathophysiology of inflammatory versus neuropathic …

Neuropathic pain is generally defined as a chronic pain state resulting from peripheral
and/or central nerve injury. Effective treatment for neuropathic pain is still lacking, due in part …

Melzack and Wall's Gate Control Theory of Pain laid the theoretical groundwork for a role of
spinal inhibition in endogenous pain control. While the Gate Control Theory was based on …

The prevalence and severity of many chronic pain syndromes differ across sex, and recent
studies have identified differences in immune signalling within spinal nociceptive circuits as …