Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and genetics

AM Buch, C Liston - Neuropsychopharmacology, 2021 - nature.com
Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …

Cardiometabolic risk factors in South American children: A systematic review and meta-analysis

CMH Singleton, S Brar, N Robertson, L DiTommaso… - Plos one, 2023 - journals.plos.org
Background Cardiometabolic risk factors (impaired fasting glucose, abdominal obesity, high
blood pressure, dyslipidemia) cluster in children, may predict adult disease burden, and are …

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity

JP Bradfield, S Vogelezang, JF Felix… - Human molecular …, 2019 - academic.oup.com
Although hundreds of genome-wide association studies-implicated loci have been reported
for adult obesity-related traits, less is known about the genetics specific for early-onset …

A proteomic screen of neuronal cell-surface molecules reveals IgLONs as structurally conserved interaction modules at the synapse

FM Ranaivoson, LS Turk, S Ozgul, S Kakehi… - Structure, 2019 - cell.com
In the developing brain, cell-surface proteins play crucial roles, but their protein-protein
interaction network remains largely unknown. A proteomic screen identified 200 interactions …

The impact of variants in four genes: MC4R, FTO, PPARG and PPARGC1A in overweight and obesity in a large sample of the Brazilian population

GV Castro, AFS Latorre, FP Korndorfer… - Biochemical …, 2021 - Springer
Obesity and overweight are worldwide public health problems with an evident genetic
predisposition that is still poorly understood. In addition, great variability has been described …

The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population

ACP da Fonseca, GM Abreu… - … and Obesity: Targets …, 2019 - Taylor & Francis
Background: Obesity occurs due to the interaction between the genetic background and
environmental factors, including an increased food intake and a sedentary lifestyle …

Obesity-related loci in TMEM18, CDKAL1 and FAIM2 are associated with obesity and type 2 diabetes in Chinese Han patients

J Kang, RC Guan, Y Zhao, Y Chen - BMC Medical Genetics, 2020 - Springer
Background Several obesity susceptibility loci in genes, including GNPDA2, SH2B1,
TMEM18, MTCH2, CDKAL1, FAIM2, and MC4R, have been identified by genome-wide …

Genetic risk score based on fat mass and obesity-associated, transmembrane protein 18 and fibronectin type III domain containing 5 polymorphisms is associated with …

PF Todendi, EI Klinger, ACR Geraldo… - British Journal of …, 2019 - cambridge.org
The prevalence of childhood obesity has increased worldwide. Although it is considered a
polygenic inheritance disease, little is known about its susceptibility when the additive effect …

BDNF Gene as a Precision Skill of Obesity Management

H Marcos-Pasero, E Aguilar-Aguilar… - Recent Advances in …, 2021 - Springer
The scarcity of the results obtained for the treatment of obesity leads us to consider new
strategies, contemplating all the factors involved in the development of the disease. One of …

Association between genetic obesity susceptibility and mother‐reported eating behaviour in children up to 5 years

B de Lauzon‐Guillain, YA Koudou, J Botton… - Pediatric …, 2019 - Wiley Online Library
Background Many genetic polymorphisms identified by genome‐wide association studies
for adult body mass index (BMI) have been suggested to regulate food intake. Objective The …