Maintaining homeostatic control of periodontal bone tissue

JD Hathaway‐Schrader, CM Novince - Periodontology 2000, 2021 - Wiley Online Library
Alveolar bone is a unique osseous tissue due to the proximity of dental plaque biofilms.
Periodontal health and homeostasis are mediated by a balanced host immune response to …

Virulence and Pathogenicity Properties of Aggregatibacter actinomycetemcomitans

GN Belibasakis, T Maula, K Bao, M Lindholm… - Pathogens, 2019 - mdpi.com
Aggregatibacter actinomycetemcomitans is a periodontal pathogen colonizing the oral cavity
of a large proportion of the human population. It is equipped with several potent virulence …

Oral-gut-brain axis in experimental models of periodontitis: associating gut dysbiosis with neurodegenerative diseases

LD Sansores-España, S Melgar-Rodríguez… - Frontiers in …, 2021 - frontiersin.org
Periodontitis is considered a non-communicable chronic disease caused by a dysbiotic
microbiota, which generates a low-grade systemic inflammation that chronically damages …

Regulatory T cell phenotype and anti-osteoclastogenic function in experimental periodontitis

C Alvarez, S Suliman, R Almarhoumi, ME Vega… - Scientific Reports, 2020 - nature.com
The alveolar bone resorption is a distinctive feature of periodontitis progression and
determinant for tooth loss. Regulatory T lymphocytes (Tregs) display immuno-suppressive …

Aggregatibacter actinomycetemcomitans, a potent immunoregulator of the periodontal host defense system and alveolar bone homeostasis

BA Herbert, CM Novince… - Molecular oral …, 2016 - Wiley Online Library
Aggregatibacter actinomycetemcomitans is a perio‐pathogenic bacteria that has long been
associated with localized aggressive periodontitis. The mechanisms of its pathogenicity …

Virulence factors of the periodontal pathogens: tools to evade the host immune response and promote carcinogenesis

LA Shahoumi, MHA Saleh, MM Meghil - Microorganisms, 2023 - mdpi.com
Periodontitis is the most common chronic, inflammatory oral disease that affects more than
half of the population in the United States. The disease leads to destruction of the tooth …

Serotype b of Aggregatibacter actinomycetemcomitans triggers pro-inflammatory responses and amyloid beta secretion in hippocampal cells: a novel link between …

J Díaz-Zúñiga, Y Muñoz… - Journal of oral …, 2019 - Taylor & Francis
Introduction: Previous reports have proposed that Periodontal disease (PDis) predisposes to
Alzheimer's disease (AD), both highly prevalent pathologies among the elderly. The bacteria …

Interleukin‐35 inhibits alveolar bone resorption by modulating the Th17/Treg imbalance during periodontitis

EA Cafferata, C Terraza‐Aguirre… - Journal of Clinical …, 2020 - Wiley Online Library
Aim T lymphocytes play a central role during the pathogenesis of periodontitis, and the
imbalance between the pathogenic T‐helper type 17 (Th17) and protective T‐regulatory …

Periodontal bacteria in the brain—Implication for Alzheimer's disease: a systematic review

V Parra‐Torres, S Melgar‐Rodríguez… - Oral …, 2023 - Wiley Online Library
Periodontitis is a chronic non‐communicable disease caused by a dysbiotic microbiota.
Pathogens can spread to the bloodstream, colonize other tissues or organs, and favor the …

Rheumatoid Arthritis-Associated Autoimmunity Due to Aggregatibacter actinomycetemcomitans and Its Resolution With Antibiotic Therapy

A Mukherjee, V Jantsch, R Khan, W Hartung… - Frontiers in …, 2018 - frontiersin.org
Background: Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative
coccobacillus recognized as a pathogen in periodontitis and infective endocarditis. By …