Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a
wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are …

Metastasis, the dissemination of cancer cells from primary tumors, represents a major hurdle
in the treatment of cancer. The epithelial-mesenchymal transition (EMT) has been studied in …

The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator β-
catenin controls embryonic development and adult homeostasis. Here we review recent …

Aging is a leading risk factor for cancer. While it is proposed that age-related accumulation
of somatic mutations drives this relationship, it is likely not the full story. We show that aging …

Neurons in the central nervous system (CNS) lose their ability to regenerate early in
development, but the underlying mechanisms are unknown. By screening genes …

Abstract Kruppel-like factor 4 (KLF4) is highly expressed in more than 70% of breast cancers
and functions as an oncogene. However, an exact mechanism by which KLF4 enhances …

Goblet cells are mucin-secreting intestinal cells forming the mucus layer that protects the
mucosal surface. Ulcerative colitis (UC) has been associated with a defective colonic mucus …

Dysregulation of transcription factors has been implicated in a variety of human diseases.
However, these proteins have traditionally been regarded as undruggable and only a …

The Krüppel-like factors (KLFs) comprise a family of evolutionarily conserved zinc finger
transcription factors that regulate numerous biological processes including proliferation …