Developmental changes in children can affect the disposition and clinical effects of a drug,
indicating that scaling an adult dose simply down per linear weight can potentially lead to …

The liver represents a major eliminating and detoxifying organ, determining exposure to
endogenous compounds, drugs, and other xenobiotics. Drug transporters (DTs) and drug …

The structural variability data of drug transporter (DT) are key for research on precision
medicine and rational drug use. However, these valuable data are not sufficiently covered …

The absorption, distribution and excretion of drugs are largely determined by their
transporters (DTs), the variability of which has thus attracted considerable attention. There …

The role of membrane transporters on pharmacokinetics (PKs), drug–drug interactions
(DDIs), pharmacodynamics (PDs), and toxicity of drugs has been broadly recognized …

Pediatric drug development faces many difficulties. Traditionally, pediatric drug doses are
simply calculated linearly based on the body weight, age, and body surface area of adults …

Organic cation transporters (OCT), organic anion transporting polypeptides (OATP) and
organic anion transporters (OAT) from the solute carrier (SLC) family play an essential role …

The past 4 decades have witnessed enormous leaps in understanding of the acute and long-
term impacts of neonatal pain and stress. Healthy infants experience roughly 12 skin …

The development of age-appropriate formulations should focus on dosage forms that can
deliver variable yet accurate doses that are safe and acceptable to the child, are matched to …

Physiologically-based pharmacokinetic (PBPK) models have progressed stratified dosing in
populations by accounting for attributes that affect pharmacokinetics. The approach has four …