HSV type-1 and-2 are widespread pathogens producing lifelong infection with multiple
sequelae, including oral, ocular and genital disease. The process of herpesvirus entry is a …

Herpes simplex virus type‐1 and type‐2 are highly prevalent human pathogens causing life‐
long infections. The process of infection begins when the virions bind heparan sulfate …

In recent years, many compounds having potent antiviral activity in cell culture have been
detected and some of these compounds are currently undergoing either preclinical or …

Many protein ligands bind to heparan sulfate, which results in their presentation, protection,
oligomerization or conformational activation. Binding depends on the pattern of sulfation and …

Glycosaminoglycans (GAGs) are complex carbohydrates that are ubiquitously present on
the cell surface and in the extracellular matrix. Interactions between GAGs and pathogens …

Heparan sulfate (HS) is a highly sulfated polysaccharide and is present in large quantities
on the cell surface and in the extracellular matrix. Herpes simplex virus type 1 (HSV-1) …

Heparan sulfate (HS) and its highly modified form, 3-O-sulfated heparan sulfate (3-OS HS),
contribute strongly to herpes simplex virus type-1 (HSV-1) infection in vitro. Here we report …

Many microbial pathogens subvert proteoglycans for their adhesion to host tissues, invasion
of host cells, infection of neighbouring cells, dissemination into the systemic circulation, and …

Abstract Heparan sulphate (glucosamine) 3-O-sulphotransferase 2 (HS3ST2, also known as
3OST2) is an enzyme predominantly expressed in neurons wherein it generates rare 3-O …

Herpes simplex virus type 1 (HSV-1) infection of the corneal stroma remains a major cause
of blindness. Primary cultures of corneal fibroblasts (CF) were tested and found susceptible …