Loss of cognitive function is one the most devastating manifestations of ageing and vascular
disease. Cognitive decline is rapidly becoming an important cause of disability worldwide …

Vascular aging is a key process determining health status of aged population. Aging is an
independent cardiovascular risk factor associated to an impairment of endothelial function …

Objectives Optimizing blood pressure using near-infrared spectroscopy monitoring has been
suggested to ensure organ perfusion during cardiac surgery. Near-infrared spectroscopy is …

Objectives: To determine whether mean arterial blood pressure excursions below the lower
limit of cerebral blood flow autoregulation during cardiopulmonary bypass are associated …

Endothelial cells (ECs) line blood vessels, ie, vital conduits for oxygen and nutrient delivery
to distant tissues. While mostly present as quiescent “phalanx” cells throughout adult life …

There has been a growing awareness over the past decade that stiffening of the aorta, and
its attendant effects on hemodynamics, is both an indicator and initiator of diverse …

In this article, we present a computational multi-scale model of fully three-dimensional and
unsteady hemodynamics within the primary large arteries in the human. Computed …

Progeroid mouse models display phenotypes in multiple organ systems that suggest
premature aging and resemble features of natural aging of both mice and humans. The …

Although considered by many as the gold standard clinical measure of arterial stiffness,
carotid-to-femoral pulse wave velocity (cf-PWV) averages material and geometric properties …

BACKGROUND: Individualizing arterial blood pressure (ABP) targets during
cardiopulmonary bypass (CPB) based on cerebral blood flow (CBF) autoregulation …