Many different types of cancer show a high incidence of TP53 mutations, leading to the
expression of mutant p53 proteins. There is growing evidence that these mutant p53s have …

The p53 protein is mutated in about 50% of human cancers. Aside from losing the tumor-
suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent …

Ample data indicate that mutant p53 proteins not only lose their tumour suppressive
functions, but also gain new abilities that promote tumorigenesis. Moreover, recent studies …

In its wild-type form, p53 is a major tumor suppressor whose function is critical for protection
against cancer. Many human tumors carry missense mutations in the TP53 gene, encoding …

TP53 missense mutations produce a mutant p53 protein that cannot activate the p53 tumor
suppressive transcriptional response, which is the primary selective pressure for TP53 …

In addition to the loss of wild-type p53 activity, a high percentage of tumor cells accumulate
mutant p53 protein isoforms. Whereas the hallmark of the wild-type p53 is its tumor …

Abstract p53 is the most frequently mutated tumor-suppressor gene in human cancers.
Unlike other tumor-suppressor genes, p53 mutations mainly occur as missense mutations …

Uncontrolled accumulation of reactive oxygen species (ROS) causes oxidative stress and
induces harmful effects. Both high ROS levels and p53 mutations are frequent in human …

It is well accepted that expression of mutant p53 involves the gain of oncogenic-specific
activities accentuating the malignant phenotype. Depending on the specific cancer type …

The mechanisms underlying the proapoptotic effect of the chemotherapeutic agent, cisplatin,
are largely undefined. Understanding the mechanisms regulating cisplatin cytotoxicity may …